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, Volume 35, Issue 1–2, pp 96–103 | Cite as

Effects of the immunomodulator diacetyl-splenopentin on antigen-induced arthritis in rabbits

  • R. Bräuer
  • K. Thoss
  • S. Henzgen
  • G. Waldmann
Inflammation and Immunomodulation

Abstract

Long-term treatment with the immunomodulator diacetyl-splenopentin reduces the severity of chronic joint inflammation and cartilage destruction in rabbits with antigen-induced arthritis. The level of specific antibodies as well as specific and non-specific cell-mediated immune reactivities including the proliferative response of spleen lymphocytes to cartilage proteoglycans in treated animals are lower than in untreated arthritic rabbits. Moreover, suppressor cell activity, which normally decreases during the early phase of inflammation, is enhanced and hyperreactive helper cell potential is reduced. These findings suggest that treatment with diacetyl-splenopentin normalizes the immune regulation, which is disturbed in the early phase of inflammation. This might result in a depression of the hyperreactive immune system including the autoimmunity developed against cartilage. Lowered immune reactivity in the joint in turn reduces the severity of chronic joint inflammation.

Keywords

Immune Reactivity Arthritis Cell Activity Early Phase Specific Antibody 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag 1992

Authors and Affiliations

  • R. Bräuer
    • 1
  • K. Thoss
    • 1
  • S. Henzgen
    • 1
  • G. Waldmann
    • 1
  1. 1.Institute of PathologyFriedrich Schiller UniversityJenaFederal Republik of Germany

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