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Clinical expression and diagnosis of atypical cortical degenerative syndromes

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Abstract

Atypical cortical degenerative syndromes of the non-Alzheimer's disease type are becoming increasingly recognized in the literature. Three cases consisting of primary progressive aphasia, posterior cortical atrophy, and frontal lobe dementia of the non-Alzheimer's type are presented to replicate and extend emerging literature. Detailed clinical description and neuropsychological data, coupled with confirmatory neurofunctional imaging, are presented to provide empirical support that specific inclusion and exclusion criteria can be applied to clinically diagnosis atypical degenerative cortical dementias.

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References

  • Auchus, A. P., Goldstein, F. C., Green, J., & Green, R. C. (1994). Unawareness of cognitive impairments in Alzheimer's disease.Neuropsychiatry, Neuropsychology, and Behavioral Neurology, 7 25–29.

    Google Scholar 

  • Benson, D. F. (1989). Posterior cortical atrophy: A new clinical entity or Alzheimer's disease?Archives of Neurology, 46 844.

    Google Scholar 

  • Benson, D. F., Davis, R. J., & Snyder, B. D. (1988). Posterior cortical atrophy.Archives of Neurology, 45 789–793.

    PubMed  Google Scholar 

  • Berg, L. (1982). Mild senile dementia of the Alzheimer type: Diagnostic criteria and natural history.The Mount Sinai Journal of Medicine, 55 87–96.

    Google Scholar 

  • Caselli, R. J. (1990). The syndrome of focal cerebral degeneration: Clinical, anatomic, and single photon emission computed tomography (SPECT) correlations.Neurology, 40 (Suppl.), 175.

    PubMed  Google Scholar 

  • Caselli, R. J., & Jack, C. R. (1992). Asymmetric cortical degenerative syndromes: A proposed classification.Archives of Neurology, 49 770–780.

    PubMed  Google Scholar 

  • Cogan, D. G. (1985). Visual disturbances with focal progressive dementing disease.American Journal of Ophthalmology, 100 68–72.

    PubMed  Google Scholar 

  • Cummings, J. L., & Benson, D. F. (1992).Dementia: A clinical approach (2nd ed.). Boston: Butterworth-Heinemann.

    Google Scholar 

  • DeKosky, S. T., Shih, W.-J., Schmitt, F. A., Coupal, J., & Kirkpatrick, C. (1990). Assessing utility of single photon emission computed tomography (SPECT) scan in Alzheimer Disease: Correlation with cognitive severity.Alzheimer's Disease and Associated Disorders, 4 14–23.

    Google Scholar 

  • Devous, M. D. (1992). Comparison of SPECT applications in neurology and psychiatry.Journal of Clinical Psychiatry, 53 (Suppl.), 13–19.

    Google Scholar 

  • Golden, C. J. (1978).Stroop Color and Word Test: A manual for clinical and experimental uses. Chicago: Stoelting.

    Google Scholar 

  • Goodglass, H., & Kaplan, E. (1983).The assessment of aphasia and related disorders. Philadelphia: Lea & Febiger.

    Google Scholar 

  • Grigsby, J., Kaye, K., & Robbins, L. J. (1992). Reliabilities, norms and factor structure of the Behavioral Dyscontrol Scale.Perceptual and Motor Skills, 74 883–892.

    PubMed  Google Scholar 

  • Gustafson, L., Brun, A., & Risberg, J. (1990). Frontal lobe dementia of non-Alzheimer's type.Advances in Neurology, 51 65–71.

    PubMed  Google Scholar 

  • Heaton, R. K. (1981).Wisconsin Card Sorting Test manual. Odessa, FL: Psychological Assessment Resources.

    Google Scholar 

  • Hooper, H. E. (1985).Hooper Visual Organization Test. Los Angeles: Western Psychological Services.

    Google Scholar 

  • Knopman, D. S., Mastri, A. R., Frey, W. H., Sung, J. H., & Rustan, T. (1990). Dementia lacking distinctive histologic features: A common non-Alzheimer degenerative dementia.Neurology, 40 251–256.

    PubMed  Google Scholar 

  • McDaniel, K. D., Wagner, M. T., & Greenspan, B. S. (1991). The role of brain single photon emission computed tomography in the diagnosis of primary progressive aphasia.Archives of Neurology, 48 1257–1260.

    PubMed  Google Scholar 

  • McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984). Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease.Neurology, 34 939–943.

    PubMed  Google Scholar 

  • Mesulam, M.-M. (1982). Slowly progressive aphasia without generalized dementia,Annals of Neurology, 11 592–598.

    Article  PubMed  Google Scholar 

  • Morris, J. C., Heyman, A., Mohs, R. C., Hughes, J. P., van Belle, G., Fillenbaum, G., Mellits, E. D., Clark, C., and the CERAD investigators (1989). The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). 1. Clinical and neuropsychological assessment of Alzheimer's disease.Neurology, 39 1159–1165.

    PubMed  Google Scholar 

  • Moss, M. B., Albert, M. S., & Kemper, T. L. (1992). Neuropsychology of frontal lobe dementia. In R. F. White (Ed.),Clinical syndromes in adult neuropsychology: The practioner's handbook. New York: Elsevier Science.

    Google Scholar 

  • National Institutes of Health Consensus Development Conference Statement (1987). Differential diagnosis of dementing diseases.Journal of the American Medical Association, 258 3411–3416.

    Google Scholar 

  • Neary, D., & Snowden, J. S. (1991). Dementia of the frontal lobe type. In H. S. Levin, H. M. Eisenberg, & A. L. Benton (Eds.),Frontal lobe function and dysfunction (pp. 304–317). New York: Oxford University Press.

    Google Scholar 

  • Neary, D., Snowden, J. S., Shields, R. A., Burjan, A. W., Northen, B., MacDermott, N., Prescott, M. C., & Testa, H. J. (1987). Single photon emission tomography using 99mTc-HM-PAO in the investigation of dementia.Journal of Neurology, Neurosurgery and Psychiatry, 50 1101–1109.

    Google Scholar 

  • Neary, D., Snowden, J. S., Northen, B., & Goulding, P. (1988). Dementia of the frontal lobe type.Journal of Neurology, Neurosurgery, and Psychiatry, 51 353–361.

    Google Scholar 

  • Reitan, R. M., & Wolfson, D. (1985).The Halstead-Reitan Neuropsychological Test Battery. Tucson: Neuropsychological Press.

    Google Scholar 

  • Ross, G. W., Benson, D. F., Verity, A. M., & Victoroff, J. I. (1990). Posterior cortical atrophy.Neurology, 40 (Suppl.), 200.

    Google Scholar 

  • Spreen, O., & Stauss, E. (1991).A compendium of neuropsychological tests: Administration, norms, and commentary. New York: Oxford Press.

    Google Scholar 

  • Talland, G. A. (1965).Deranged memory. New York: Academic Press.

    Google Scholar 

  • Teri, L., Truax, P., Logsdon, R., Uomoto, J., Zarit, S., & Vitaliano, P. P. (1992). Assessment of behavioral problems in dementia: The revised Memory and Behavior Problem Checklist.Psychology and Aging, 7 622–631.

    Article  PubMed  Google Scholar 

  • Victoroff, J., Ross, G. W., Benson, D. F., Verity, M. A., & Vinters, H. V. (1994) Posterior cortical atrophy: Neuropathologic correlations.Archives of Neurology, 51 269–274.

    PubMed  Google Scholar 

  • Wagner, M. T., & Cushman, L. (1994). Neuroanatomic and neuropsychological predictors of unawareness of cognitive deficit in the vascular population.Archives of Clinical Neuropsychology, 957–69.

  • Wechsler, D. (1981).Wechsler Adult Intelligence Scale—revised: Manual. San Antonio: Psychological Corp.

    Google Scholar 

  • Wechsler, D. (1987).Wechsler Memory Scale—revised: Manual. San Antonio: Psychological Corp.

    Google Scholar 

  • Weintraub, S., & Mesulam, M. (1994). Four neuropsychological profiles of dementia. In F. Boller & J. Grafman, (Eds.),Handbook of Neuropsychology (pp. 253–289). New York: John Wiley and Sons.

    Google Scholar 

  • Yesavage, J. A., Brink, T. L., Rose, T. L., Lum, O., Huang, V., Adey, M., & Leirer, V. O. (1983). Development and validation of a geriatric depression screening scale: A preliminary report.Journal of Psychiatric Research, 17 37–49.

    Article  Google Scholar 

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Correspondence to Mark T. Wagner.

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Wagner, M.T., Bachman, D.L. & Spicer, K.M. Clinical expression and diagnosis of atypical cortical degenerative syndromes. J Clin Psychol Med Settings 2, 275–288 (1995). https://doi.org/10.1007/BF01990882

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