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Experientia

, Volume 31, Issue 2, pp 233–234 | Cite as

Chloroquine et sérotonine plaquettaire. Mise en évidence d'une inhibition compétitive de la captation de sérotonine

  • M. Lagarde
  • M. Dechavanne
  • P. A. Bryon
Specialia

Summary

On electron microscopy, platelets exposed to chloroquine exhibit no abnormality, except for surface connecting system. However, when platelets were labelled with14C serotonin, there was liberation of a large amount of radioactivity which is inhibited when the extracellular concentration of serotonin is increased. It appears that chloroquine is a competitive inhibitor of serotonin uptake by platelets.

References

  1. 1.
    F. Jobin etF. Tremblay, Thromb. Diath. Haemorrh.22, 466 (1969).PubMedGoogle Scholar
  2. 2.
    A. E. Carter, R. Eban etR. D. Perret, Br. med. J.1, 312 (1971).PubMedGoogle Scholar
  3. 3.
    M. Fedorko, J. clin. Invest.46, 1932 (1967).PubMedGoogle Scholar
  4. 4.
    M. Fedorko, J. G. Hirsch etZ. A. Cohn, J. Cell. Biol.38, 377 (1968).CrossRefPubMedGoogle Scholar
  5. 5.
    M. Fedorko, J. G. Hirsch etZ. A. Cohn, J. Cell. Biol.38, 392 (1968).CrossRefPubMedGoogle Scholar
  6. 6.
    J. F. Mustard, D. W. Perry, N. G. Ardlie etM. A. Packham, Br. J. Haemat.22, 193 (1972).Google Scholar
  7. 7.
    C. S. P. Jenkins, M. A. Packham, R. L. Kinlough-Rathbone etJ. F. Mustard, Blood37, 395 (1971).PubMedGoogle Scholar
  8. 8.
    H. U. Bergmeyer, E. Bernt etB. Hess,Methods of Enzymatic Analysis (Bergmeyer, New York 1963), p. 117.Google Scholar
  9. 9.
    G. V. R. Born etR. E. Gillson, J. Physiol., Lond.146, 472 (1959).Google Scholar
  10. 10.
    P. A. Bryon, M. Dechavanne, J. P. Thouverez etL. Revol, C.r. Soc. Biol., Paris166, 893 (1972).Google Scholar
  11. 11.
    F. Michal, Nature, Lond.221, 1253 (1969).Google Scholar

Copyright information

© Birkhäuser Verlag 1975

Authors and Affiliations

  • M. Lagarde
    • 1
    • 2
    • 3
  • M. Dechavanne
    • 1
    • 2
    • 3
  • P. A. Bryon
    • 1
    • 2
    • 3
  1. 1.Laboratoire d'HémostaseInstitut PasteurLyonFrance
  2. 2.Laboratoire de Médecine Nucléaire appliquée à l'HématologieHôpital Edouard Herriot, Pavillon E bisLyon Cédex 02France
  3. 3.Laboratoire d'Histohématologie et Microscopie électroniqueLyonFrance

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