Experientia

, Volume 31, Issue 2, pp 215–218 | Cite as

A negative cooperative binding process between chloramphenicol and sodium dodecyl sulphate to bovine serum albumin: A possible effect on drug absorption

  • F. Alhaique
  • M. Marchetti
  • F. M. Riccieri
  • Eleonora Santucci
Specialia

Keywords

Sodium Sulphate Albumin Bovine Serum Bovine Serum Albumin 

Résumé

L'étude de l'influence de concentrations prémicellaires des tensioactifs sur l'interaction BSA-CAF permet de conclure qu'il s'agit d'un mécanisme cooperatif suivant le modèle allosterique proposé parMonod, Wyman etChangeux. Ce mécanisme représente une possible explication de l'influence des tensioactifs sur l'absorption des médicaments.

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Copyright information

© Birkhäuser Verlag 1975

Authors and Affiliations

  • F. Alhaique
    • 1
  • M. Marchetti
    • 1
  • F. M. Riccieri
    • 1
  • Eleonora Santucci
    • 1
  1. 1.Cattedra di Tecnica Farmaceutica, Istituto di ChimicaFarmaceutica dell'Università di RomaRomaItaly

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