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Rapid appearance of histamine hypersensitivity in mice by minute dose of endotoxins

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Riassunto

È dimostrato che l'apparizione rapida entro 60 min dell'ipersensibilità a istamina è indotta nei topi con dosi minime, come nanogrammi per topo, di tutte le sorti di endotossine esaminate. La risposta dipende dall'età del topo. La relazione fra il logaritmo della dose di endotossina e la mortalità, la dose d'istamine essendo costante, non è lineare; ma risulta una curva con un massimo, «unimodal dose-response curve».

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Authors and Affiliations

  1. Department of General Biologics Control, National Institute of Health, Kamiosaki 2-10-35, Shinagawa-ku, 141, Tokyo, Japan

    K. Kuratsuka, R. Homma, Y. Shimazaki & I. Funasaka

Authors
  1. K. Kuratsuka
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  2. R. Homma
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  3. Y. Shimazaki
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  4. I. Funasaka
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Additional information

The major part of this paper was read at the 29th General Meeting of Kanto Region of Japan Bacteriological Society in 197312.

Acknowledgment: Thanks are due to Dr.M. Kurokawa, Director of the Department, for his kind suggestions.

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Kuratsuka, K., Homma, R., Shimazaki, Y. et al. Rapid appearance of histamine hypersensitivity in mice by minute dose of endotoxins. Experientia 31, 206–208 (1975). https://doi.org/10.1007/BF01990708

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