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Blocking of lectin-like adhesion molecules on pulmonary cells inhibits lung sarcoma L-1 colonization in BALB/c-mice

Experientia volume 45, pages 584–588 (1989)Cite this article

Summary

Adhesion and inhibition experiments with pulmonary cells of BALB/c-mouse origin and syngeneic sarcoma L-1 cells indicated that L-fucose specific lectin-like adhesion molecules, presumably situated on pulmonary cell surfaces are (at least partly) responsible for the specificity of this cell-cell interaction. Addition of specific sugars and glycoconjugates (L-fucose and fucoidan, respectively) to the incubation medium evidently inhibited the adhesion process as quantified using radiolabelled tumor cells. Unspecific carbohydrates (e.g. D-galactose) did not affect the cellular interaction. In vivo, repeated administration of fucoidan (but not of unspecific glycoconjugates) significantly inhibited the settling of metastatic sarcoma L-1 cells in the lungs of BALB/c-mice. Therefore, when lectin-like adhesion molecules on pulmonary cells were blocked with competitive glycoconjugates, tumor cell colonization of the lung could be significantly inhibited.

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Author information

Affiliations

  1. National Institute of Lung Diseases and Tuberculosis, Warsaw, Poland

    W. Roszkowski

  2. Institute of Hygiene, University of Cologne, Goldenfelsstrasse 19–21, D-5000, Cologne, Germany

    J. Beuth, H. L. Ko & G. Pulverer

  3. Institute of Immunobiology, University of Cologne, D-5000, Cologne, Germany

    G. Uhlenbruck

Authors
  1. W. Roszkowski
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  2. J. Beuth
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  3. H. L. Ko
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  4. G. Uhlenbruck
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  5. G. Pulverer
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Roszkowski, W., Beuth, J., Ko, H.L. et al. Blocking of lectin-like adhesion molecules on pulmonary cells inhibits lung sarcoma L-1 colonization in BALB/c-mice. Experientia 45, 584–588 (1989). https://doi.org/10.1007/BF01990514

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  • DOI: https://doi.org/10.1007/BF01990514

Keywords

  • Glycoprotein
  • sarcoma L-1 tumor cells
  • L-fucose
  • fucoidan
  • lung metastasis
  • BALB/c-mice