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Fibrin and collagen deposition and fibroblasts proliferation in granuloma of murine leprosy. Comparison of two mouse strains with different immune reactions

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Summary

Comparative immunofluorescence study with murine lepromas induced in C57BL/6NJcl (immunologically high responder) and CBA/N (low responder) mouse strains revealed that fibrin formation was associated with cellmediated immune resistance against invasive bacilli. Histochemistry on paraffin sections further elucidated fibroblast proliferation and formation of collagen fibers following fibrin deposition only in murine lepromas with positive host reactions.

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Authors and Affiliations

  1. Department of Dermatology, Iwate Medical University, School of Medicine, 020, Morioka, Iwate, Japan

    M. Satoh, S. Izaki, S. Kon & M. Izaki

Authors
  1. M. Satoh
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  2. S. Izaki
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  3. S. Kon
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  4. M. Izaki
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Additional information

This study was supported by grants from: Iwate Medical University-Keiryokai Research Foundation Japanese Dermatological Association-Basic Medical Research Aid, and Ohyama Health Foundation.

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Satoh, M., Izaki, S., Kon, S. et al. Fibrin and collagen deposition and fibroblasts proliferation in granuloma of murine leprosy. Comparison of two mouse strains with different immune reactions. Experientia 39, 899–902 (1983). https://doi.org/10.1007/BF01990428

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