Skip to main content
SpringerLink
Log in

Low doses of 2,4,5-trichlorophenoxyacetic acid are behaviorally teratogenic to rats

  • Short Communications
  • Pharmacology, Tocicology
  • Published:
Experientia Aims and scope Submit manuscript

Summary

Pre-natal exposure of rats to 2,4,5-T has long-term effects on behavior. A test for novelty responding detects abnormalities after exposure to a single dose as low as 6 mg/kg on day 8 of gestation. This is well below doses reported to be morphologically teratogenic, and raises concern for human exposure.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Sanderson, C. A., and Rogers, L. J., Science211 (1981) 593.

    Article  CAS  Google Scholar 

  2. Khera, K. S., and McKinley, W. P., Toxic. appl. Pharmac.22 (1972) 14.

    Article  CAS  Google Scholar 

  3. Sjödén, P-O., and Söderberg, U., Exol. Bull. Stockholm27 (1978) 149.

    Google Scholar 

  4. Sjödén, P-O., and Söderberg, U., Physiol. Psychol.3 (1975) 175; Physiol. Behav.9 (1972) 357.

    Article  Google Scholar 

  5. Candland, D. K., and Nagy, Z. M., Ann. N. Y. Acad. Sci.159 (1969) 831.

    Article  CAS  PubMed  Google Scholar 

  6. Candland, D. K., and Campbell, B. A., J. comp. Physiol. Psychol.55 (1962) 593.

    Article  Google Scholar 

  7. Whimbley, A. E., and Denenberg, V. H., J. comp. Physiol. Psychol.63 (1967) 500.

    Article  Google Scholar 

  8. Murray, F. J., Smith, F. A., Nitschke, K. D., Humiston, R. J., Kociba, P. J., and Schwetz, B. A., Toxic. appl. Pharmac.50 (1979) 241.

    Article  CAS  Google Scholar 

  9. Lavy, T. L., Shepherd, J. S., and Bouchard, D. C., Environ. Contam. Toxic.24 (1980) 90.

    Article  CAS  Google Scholar 

  10. Sjödén, P-O., Archer, T., and Carter, N., Physiol. Psychol7 (1979) 93.

    Article  Google Scholar 

  11. Rogers, L. J., and Sanderson, C. A., Science215 (1982) 1422.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmacology, Monash University, Wellington Road, 3168, Clayton, Victoria, Australia

    M. A. Crampton & L. J. Rogers

Authors
  1. M. A. Crampton
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. L. J. Rogers
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Crampton, M.A., Rogers, L.J. Low doses of 2,4,5-trichlorophenoxyacetic acid are behaviorally teratogenic to rats. Experientia 39, 891–892 (1983). https://doi.org/10.1007/BF01990423

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01990423

Keywords

Search

Navigation