Experientia

, Volume 39, Issue 8, pp 891–892 | Cite as

Low doses of 2,4,5-trichlorophenoxyacetic acid are behaviorally teratogenic to rats

  • M. A. Crampton
  • L. J. Rogers
Short Communications Pharmacology, Tocicology

Summary

Pre-natal exposure of rats to 2,4,5-T has long-term effects on behavior. A test for novelty responding detects abnormalities after exposure to a single dose as low as 6 mg/kg on day 8 of gestation. This is well below doses reported to be morphologically teratogenic, and raises concern for human exposure.

Keywords

Single Dose Human Exposure 

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Copyright information

© Birkhäuser Verlag 1983

Authors and Affiliations

  • M. A. Crampton
    • 1
  • L. J. Rogers
    • 1
  1. 1.Department of PharmacologyMonash UniversityClayton(Australia)

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