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A new anti-mycotic drug tioxaprofen and its uncoupling effect on isolated mitochondria

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  • Pharmacology, Tocicology
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Summary

An oxazole compound, tioxaprofen, exerted a strong anti-mycotic activity againstTrichophyton mentagrophytes andT. rubrum, which were major dermatophytes from patients. It was found that tioxaprofen was a potent uncoupling agent of mitochondrial respiration.

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References

  1. Kosuga, H., Med. Drug J.15 (1979) 45.

    Google Scholar 

  2. Yamaguchi, H., Jap. J. med. Mycol.22 (1981) 279.

    Article  CAS  Google Scholar 

  3. Schneider, W.C., J. biol. Chem.176 (1948) 259.

    Article  CAS  PubMed  Google Scholar 

  4. Chance, B., and Williams, G.R., Adv. Enzymol.17 (1956) 65.

    CAS  Google Scholar 

  5. Tedeschi, H., and Harris, D.L., Archs Biochem. Biophys.58 (1955) 52.

    Article  CAS  Google Scholar 

  6. Lowry, O.H., Rosenbrough, N.J., Farr, A.B., and Randall, R.J., J. biol. Chem.193 (1951) 265.

    Article  CAS  PubMed  Google Scholar 

  7. Myers, D.K., and Slater, E.C., Biochem. J.67 (1957) 558.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Lehninger, A.L., Physiol. Rev.42 (1962) 467.

    Article  CAS  PubMed  Google Scholar 

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Author notes

  1. M. Nozaki, K. Tsurumi & H. Fujimura

    Present address: Department of Biochemistry, Gifu University School of Medicine, Tsukasamachi 40, 500, Gifu, Japan

Authors and Affiliations

  1. Department of Biochemistry, Gifu University School of Medicine, Tsukasamachi 40, 500, Gifu, Japan

    K. Kawai, R. Watanabe & Y. Nozawa

Authors
  1. K. Kawai
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  2. R. Watanabe
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  3. Y. Nozawa
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  4. M. Nozaki
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  5. K. Tsurumi
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  6. H. Fujimura
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Additional information

We wish to thank Dr Shohei Watanabe and Dr Yasuo Kitajima for their kindness in supplying of dermatophytes.

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Kawai, K., Watanabe, R., Nozawa, Y. et al. A new anti-mycotic drug tioxaprofen and its uncoupling effect on isolated mitochondria. Experientia 39, 889–890 (1983). https://doi.org/10.1007/BF01990422

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  • DOI: https://doi.org/10.1007/BF01990422

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