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Time course study of the changes in blood glutathione induced by acute ethanol intoxication in the rat

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Summary

Acute ethanol treatment of rats (5 g/kg) has a biphasic effect on the glutathione content of the erythrocyte. After 3 h of intoxication there is a diminution in total GSH equivalents, followed by a recovery to basal values 6 h after treatment. The decrease of total GSH equivalents is mainly due to a diminution of the oxidized form of the tripeptide. Concomitantly a marked increase in the plasma level of glutathione was found at 3 h, followed by a diminution to values obtained at time zero.

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Authors and Affiliations

  1. Unidad de Bioquímica, División de Ciencias Médicas Occidente, Facultad de Medicina, Universidad de Chile, Correo Central, Casilla No. 10455, Santiago, Chile

    V. Fernández, N. Fernández, A. Valenzuela & L. A. Videla

  2. Laboratorio de Bioquímica, INTA, Universidad de Chile, Santiago, Chile

    V. Fernández, N. Fernández, A. Valenzuela & L. A. Videla

Authors
  1. V. Fernández
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  2. N. Fernández
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  3. A. Valenzuela
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  4. L. A. Videla
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Additional information

These studies were supported by the grant B-1162-822-3 from the Servicio de Desarrollo Cientifico, Artistico y de Cooperación Internacional, Universidad de Chile. We thank Miss 3. Almeyda and Mr. F. González for expert technical assistance.

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Fernández, V., Fernández, N., Valenzuela, A. et al. Time course study of the changes in blood glutathione induced by acute ethanol intoxication in the rat. Experientia 39, 880–882 (1983). https://doi.org/10.1007/BF01990416

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  • DOI: https://doi.org/10.1007/BF01990416

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