, Volume 39, Issue 8, pp 873–876 | Cite as

Contribution to knowledge of the biosynthesis of cyclosporin A

  • H. Kobel
  • H. R. Loosli
  • R. Voges
Short Communications Biochemistry


3H-and13C-NMR spectroscopic investigations on the structure of labeled cyclosporin A were performed after feeding of appropriate precursors. The 6 N-methyl groups and the methyl group in position 4 of the ε, Φ-unsaturated amino acid No. 1 (Mebmt) are introduced as intact CH3-units from methionine. Four head-to-tail acetate units are involved in the biosynthesis of the 8-carbon chain of the olefinic amino acid.


Methyl Acetate Methionine Cyclosporin Spectroscopic Investigation 
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Copyright information

© Birkhäuser Verlag 1983

Authors and Affiliations

  • H. Kobel
    • 1
  • H. R. Loosli
    • 1
  • R. Voges
    • 1
  1. 1.Pharmaceutical DepartmentSandoz LtdBaselSwitzerland

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