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Desensitization to histamine in the absence of external Ca++ in the guinea-pig taenia caecum

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Summary

Short-term desensitization of the contractile response of the guinea-pig taenia caecum to histamine was tested in the absence of Ca++. Desensitization was monitored both by the fall of histamine response and by the decrease of irreversible blockade by phenoxybenzamine. In Ca++-free solution with 0.2 mM EGTA, desensitization occurred as in normal physiological solution containing Ca++.

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Authors and Affiliations

  1. Department of Molecular Pharmacology, Meiji College of Pharmacy, 1-35-23 Nozawa Setagayaku, 154, Tokyo, Japan

    M. Uchida & H. Hirano

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  1. M. Uchida
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  2. H. Hirano
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Uchida, M., Hirano, H. Desensitization to histamine in the absence of external Ca++ in the guinea-pig taenia caecum. Experientia 39, 862–863 (1983). https://doi.org/10.1007/BF01990406

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  • DOI: https://doi.org/10.1007/BF01990406

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