, Volume 39, Issue 11, pp 1282–1284 | Cite as

Cholecystokinin-octapeptide-induced hyperthermia in guinea-pigs

  • S. B. Kandasamy
  • B. A. Williams
Short Communications Physiology, Pathophysiology


Intracerebroventricular administration of cholecystokinin-octapeptide (CCK-8) at room temperature (21°C) induced dose-related hyperthermia in guinea-pigs and also produced hyperthermia at low (10°C) and high (30°C) ambient temperatures. CCK-8-induced hyperthermia was direct and not mediated by prostaglandins, norepinephrine, cyclic AMP or naloxone-sensitive receptors.


Ambient Temperature Prostaglandin Norepinephrine Intracerebroventricular Administration 
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Copyright information

© Birkhäuser Verlag 1983

Authors and Affiliations

  • S. B. Kandasamy
    • 1
  • B. A. Williams
    • 1
  1. 1.Biosystems DivisionNASA-Ames Research CenterMoffett FieldUSA

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