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Formation of the active antifertility metabolite of (S)-α-chlorohydrin in boar sperm

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Summary

The male antifertility agent (S)-α-chlorohydrin (I) is metabolized by boar sperm to (S)-3-chlorolactaldehyde (II) by an enzyme that is involved in the oxidation of glycerol to glyceraldehyde. The presence of glycerol decreases the activity of this enzyme towards (S)-α-chlorohydrin in vitro thereby preventing the formation of (S)-3-chlorolactaldehyde, an inhibitor of glyceraldehyde 3-phosphate dehydrogenase in boar sperm.

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Authors and Affiliations

  1. Department of Biochemistry, The University of Sydney, 2006, Sydney, N.S.W., Australia

    A. R. Jones & D. Stevenson

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  1. A. R. Jones
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  2. D. Stevenson
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Additional information

This work was supported by an Aboriginal Study Grant and the National Health and Medical Research Council of Australia.

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Jones, A.R., Stevenson, D. Formation of the active antifertility metabolite of (S)-α-chlorohydrin in boar sperm. Experientia 39, 784–785 (1983). https://doi.org/10.1007/BF01990326

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