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Effect of specific and nonspecific immune complexes on injury of intact hepatocytes in vitro

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Summary

Immune complex (IC)-mediated cytotoxicity of hepatocytes was investigated in vitro, using antibodies against specific and nonspecific target cell surface membranes. The results indicated that neither specific, nor nonspecific IC evoked significant lysis of intact hepatocytes. Thus, the IC are unlikely to play an important role in the immune-associated injury of normal hepatocytes in acute and chronic liver diseases.

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Authors and Affiliations

  1. Laboratory for Gut/Liver Immunology Research, Veterans Adminstration Medical Center and Georgetown University Medical School, 20422, Washington, D. C., USA

    H. Kawanishi

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  1. H. Kawanishi
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Acknowledgment. This work was supported by a Veterans Administration Research Fund at Ann Arbor Veterans Administration Medical Center, Michigan, during 1977–1980.

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Kawanishi, H. Effect of specific and nonspecific immune complexes on injury of intact hepatocytes in vitro. Experientia 39, 769–771 (1983). https://doi.org/10.1007/BF01990318

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  • DOI: https://doi.org/10.1007/BF01990318

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