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Beta-endorphin immunoreactivity in the plasma of patients with the Prader-Labhart-Willi syndrome and their normal siblings

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Summary

No significant difference was found in the range or mean values of ir-β-endorphin in the plasma of 6 patients with the Prader-Labhart-Willi syndrome compared to 7 of their normal siblings. The hypothesis that some of the symptoms of the P-L-W syndrome are due to excessive opioid activity is not supported by measurment of peripheral levels of ir-β-endorphin.

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Authors and Affiliations

  1. Department of Psychology, Temple University, 19122, Philadelphia, Pennsylvania, USA

    D. L. Margules & C. E. Inturrisi

  2. Department of Pharmacology, Cornell University Medical College, 10021, New York, New York, USA

    D. L. Margules & C. E. Inturrisi

Authors
  1. D. L. Margules
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  2. C. E. Inturrisi
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Additional information

Supported in part by a grant BNS-8216104 from the National Science Foundation (DLM) and DA-01457 from the National Institute on Drug Abuse (CEI)

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Margules, D.L., Inturrisi, C.E. Beta-endorphin immunoreactivity in the plasma of patients with the Prader-Labhart-Willi syndrome and their normal siblings. Experientia 39, 766–767 (1983). https://doi.org/10.1007/BF01990316

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  • DOI: https://doi.org/10.1007/BF01990316

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