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Biologically-active sterol sulfates from the marine spongeToxadocia zumi

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  • Pharmacology, Toxicology
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Summary

Three sterol sulfates1–3 having a wide variety of biological activities were isolated from the local marine spongeToxadocia zumi. The structures were determined from spectral data.

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References

  1. Thompson, J.E., unpublished observations.

  2. Unreported data from these laboratories.

  3. Ristau, D.A., Proc. biol. Soc. Wash.91 (1978) 569. The nameToxadocia does not imply toxicity but refers to the fact that the sponge has only toxas as microscleres.

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  7. The sterol sulfates1–3 are quite soluble in water and may be washed out of the food pellet too rapidly to allow the assay results to be valid.

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Authors and Affiliations

  1. Scripps Institution of Oceanography, 92093, La Jolla, California, USA

    T. Nakatsu, R. P. Walker, J. E. Thompson & D. J. Faulkner

Authors
  1. T. Nakatsu
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  2. R. P. Walker
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  3. J. E. Thompson
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  4. D. J. Faulkner
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Additional information

Acknowledgment. We thank Kathleen Kopley, Joseph Pawlik and Catherine Steyn for technical assistance. This research was supported by grants from the National Institutes of Health (AI-11969) and National Science Foundation (OCE-8008338 and PCM-7714946).

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Nakatsu, T., Walker, R.P., Thompson, J.E. et al. Biologically-active sterol sulfates from the marine spongeToxadocia zumi. Experientia 39, 759–761 (1983). https://doi.org/10.1007/BF01990312

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  • DOI: https://doi.org/10.1007/BF01990312

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