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Bone marrow genotoxicity of N-methyl, N-nitrosourea (NMU): n-alkanols as sister chromatid exchange (SCE) anti-inducers

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Summary

The in vivo SCE test was used to demonstrate significant inhibition, of NMU bone marrow genotoxicity by pretreatment of Chinese hamsters with n-alkanols. Our findings exclude a loss of intracellular DNA alkylation potential through a competitive direct reaction of NMU with the weakly nucleophilic polar end of the n-alkanols, but not through methylations of nucleophilic membrane sites possibly liberated by structural modifications which the membrane-active amphiphilics induce.

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Authors and Affiliations

  1. Institut de Cancérologie et d'Immunogénétique, Laboratoire d'Immunopharmacologie Moléculaire, 16 Av. P.-V.-Couturier, F-94800, Villejuif, France

    K. -W. Stahl & U. Bayer

  2. Institut National de Recherches sur le Cancer, CNRS, BP No. 8, F-94800, Villejuif, France

    K. -W. Stahl & U. Bayer

  3. Zentrum Biochemie, Abt. I, Medizinische Hochschule, Konstanty-Gutschow-Str. 8, D-3000, Hannover 61, Federal Republic of Germany

    K. -W. Stahl

Authors
  1. K. -W. Stahl
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  2. U. Bayer
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Acknowledgments. NMU was kindly provided by Dr Stan Ivankovic, Deutsches Krebsforschungszentrum Heidelberg. K.-W.S. acknowledges financial support from the German Academic, Exchange Service (DAAD) as Maître de Conférence Associé de l'Université Paris XI détaché à l'I.C.I.G. U. B. was recipient of a post-doc EURATOM grant of the European Communities at the Dép. de Médecine of the I.R.S.C.

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Stahl, K.W., Bayer, U. Bone marrow genotoxicity of N-methyl, N-nitrosourea (NMU): n-alkanols as sister chromatid exchange (SCE) anti-inducers. Experientia 39, 757–759 (1983). https://doi.org/10.1007/BF01990311

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  • DOI: https://doi.org/10.1007/BF01990311

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