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Murine arylsulfatase C: Evidence for two isozymes

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Summary

SWR/J mice posses high arylsulfatase C, estrone sulfatase, and dehydroepiandrosterone sulfatase activities in liver, spleen and kidney compared to A/J mice. This internstrain activity variation appears to be determined by at least 1 autosomal gene. Murine arylsulfatase C activity occurs in both hydrophobic and hydrophilic forms which differ with respect to certain biochemical properties and exhibit different subcellular distributions. The hydrophilic isozyme is a major component in kidney and brain extracts and a minor isozyme in liver and spleen extracts. The hydrophobic arylsulfatase C isozyme appears to be identical to steroid sulfatase. The hydrophilic arylsulfatase C isozyme does not possess steroid sulfatase activity; however, hydrophilic and hydrophobic arylsulfatase C share certain properties, suggesting that they may be structurally related. The autosomal gene(s) affects both arylsulfatase isozymes.

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Authors and Affiliations

  1. Department of Biochemistry, Albert Chandler School of Medicine, University of Kentucky, 40536, Lexington, Kentucky, USA

    K. Nelson, B. M. Keinanen & W. L. Daniel

  2. Department of Genetics and Development, University of Illinois, 515 Morrill Hall, 505 South Goodwin Avenue, 61801, Urbana, Illinois, USA

    K. Nelson, B. M. Keinanen & W. L. Daniel

  3. Department of Genetics and Development, University of Illinois, 61801, Urbana, Illinois, USA

    W. L. Daniel

Authors
  1. K. Nelson
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  2. B. M. Keinanen
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  3. W. L. Daniel
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This research was supported in part by National Institutes of Health grant GM 27707.

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Nelson, K., Keinanen, B.M. & Daniel, W.L. Murine arylsulfatase C: Evidence for two isozymes. Experientia 39, 740–742 (1983). https://doi.org/10.1007/BF01990302

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