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Determination of rubindium in human serum

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  • Physiology, Pathophysiology
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Summary

Field desorption mass spectrometry (FD-MS) combined with stable isotope dilution has been used to determine rubidium concentrations from human serum. Samples obtained from 110 healthy volunteers (50 males, 60 females) were examined. The rubidium concentrations found varied from 0.96 to 3.56 μmoles/l, the average value being 1.96 μmoles/l. The precision of the measurements within a batch was 0.8%. The time for 1 analysis, including sample preparation is about 30 min, the total sample consumption is 100–200 μl. The corresponding potassium concentrations were also determined from all these serum samples; a weak trend towards higher potassium levels with increasing rubidium concentration is found.

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Author notes

  1. H. -R. Schulten

    Present address: Department of Trace Analysis, Fachhochschule Fresenius, Dambachtal 20, D-6200, Wiesbaden, Federal Republic of Germany

Authors and Affiliations

  1. Institut für Physikalische Chemie der Universität Bonn, Wegelerstr. 12, D-5300, Bonn 1, Federal Republic of Germany

    H. -R. Schulten, P. B. Monkhouse, C. Achenbach & R. Ziskoven

  2. Physiologisches Institut II der Universität Bonn, Wilhelmstr. 31, D-5300, Bonn 1, Federal Republic of Germany

    H. -R. Schulten, P. B. Monkhouse, C. Achenbach & R. Ziskoven

Authors
  1. H. -R. Schulten
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  2. P. B. Monkhouse
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  3. C. Achenbach
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  4. R. Ziskoven
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Additional information

This work was generously supported by the Umweltbundesamt, Berlin (F+E Vorhaben Nr. 10660013/04) and the Deutsche Forschungsgemeinschaft, Bonn. The authors are grateful to P. Lemke, Institute of Physiology II, for technical assistance and A. Schneider, University Polyclinic, for preparation of serum samples.

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Schulten, H.R., Monkhouse, P.B., Achenbach, C. et al. Determination of rubindium in human serum. Experientia 39, 736–738 (1983). https://doi.org/10.1007/BF01990300

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