Summary
The effect of SKF-525A and phenobarbirtal on the LD50 values of vinblastine and vincristine suggests that the toxicity of these agents in mice does not arise from a toxic metabolite.
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References
P. Calabresi andR. E. Parks, inThe Pharmacological Basis of Therapeutics, 5th ed. (Eds.L. S. Goodman andA. Gilman; Macmillan Co., New York 1975), p. 1284.
J. G. Armstrong, Cancer Chemother. Rep.52, 527 (1968).
C. T. Beer andJ. F. Roberts, Lloydia27, 352 (1964).
R. J. Owellen andD. W. Donigan, J. med. Chem.15, 894 (1972).
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This work was supported by PHS Grant No. GM 15956. The author wishes to thankMary-Lucille Mantz for her valuable technical assistance and the Eli Lilly Company for graciously providing generous samples of VLB and VCR. The ample gift of SKF-525A from Smith, Kline and French Laboratories is also gratefully acknowledged.
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Fitzgerald, T.J. Phenobarbital and SKF-525A on vinblastine and vincristine toxicity in mice. Experientia 32, 619–620 (1976). https://doi.org/10.1007/BF01990197
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DOI: https://doi.org/10.1007/BF01990197