Influence of cyclic nucleotides on protein synthesis in vascular smooth muscle

Summary

The incorporation of leucice-¹⁴C into protein in bovine mesenteric arteries was augmented by cyclic GMP (10⁻³ M) and decreased by cyclic AMP (10⁻³ M). There was no effect of 5′ AMP (10⁻³ M). The phosphodiesterase inhibiting drugs theophylline (10⁻³ M) and papaverine (5×10⁻⁵ g/ml) both decreased the leucine-¹⁴C incorporation.