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Increased dihydrofolate reductase, double minutes and increased nucleolar activation in methotrexate-resistant HeLa cells

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Summary

HeLa cells resistant to methotrexate exhibit increased production of dihydrofolate reductase, double minutes and increased activity of the nucleolar organizing regions.

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Authors and Affiliations

  1. Hellenic Anticancer Institute, Papanicolaou Research Center, 171, Alexandras Avenue, 603, Athens, Greece

    J. G. Delinassios & M. J. Talieri

Authors
  1. J. G. Delinassios
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  2. M. J. Talieri
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Acknowledgment. We thank Miss M. Margaronis for excellent technical assistance.

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Delinassios, J.G., Talieri, M.J. Increased dihydrofolate reductase, double minutes and increased nucleolar activation in methotrexate-resistant HeLa cells. Experientia 39, 1394–1395 (1983). https://doi.org/10.1007/BF01990122

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  • DOI: https://doi.org/10.1007/BF01990122

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