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cAMP in guinea-pig superior cervical ganglia during preganglionic nerve stimulation

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Summary

Preganglionic nerve stimulation or elevated [K+]0 increase cAMP levels in isolated guinea-pig superior cervical ganglia, a ganglion lacking adrenergic inhibitory synaptic potentials. The cAMP response to K+ and nerve stimulation is not prevented by atropine or phentolamine. The regulation of cAMP content does not involve cholinergic or adrenergic mechanism. Of polypeptides tested, only VIP (5×10−6 M) increases cAMP content to the extent observed with preganglionic nerve stimulation.

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Authors and Affiliations

  1. Department of Pharmacology, University of Connecticut, 06032, Farmington, Connecticut, USA

    R. L. Volle & B. Patterson

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  1. R. L. Volle
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  2. B. Patterson
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Supported by grant No. 07540-15 from Neurological Institutes of Neurological and Communicative Diseases, National Institutes of Health, Bethesda, MD.

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Volle, R.L., Patterson, B. cAMP in guinea-pig superior cervical ganglia during preganglionic nerve stimulation. Experientia 39, 1345–1346 (1983). https://doi.org/10.1007/BF01990094

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  • DOI: https://doi.org/10.1007/BF01990094

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