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Effects of duration of gonadectomy, sex and age on adrenal steroid 5α-reductase activity in the rat

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Summary

Within 6–8 weeks, gonadectomy in male and female rats leads to an increase in adrenal 5α-steroid reductase activity. However, long-term post-orchiectomy enzyme activity decreases to the control level and this effect is not related to the age of animals.

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Authors and Affiliations

  1. Department of Histology and Embryology, Institute of Biostructure, Poznań Academy of Medicine, 6 Święcicki Str., PL-60-781, Poznań, Poland

    L. K. Malendowicz & P. Fichna

Authors
  1. L. K. Malendowicz
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  2. P. Fichna
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Additional information

Supported in part by grant No.564/VI from Polish Academy of Sciences. Generous gift of hormones applied in these studies from The Upjohn Company, Kalamazoo, Michigan, USA is acknowledged.

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Malendowicz, L.K., Fichna, P. Effects of duration of gonadectomy, sex and age on adrenal steroid 5α-reductase activity in the rat. Experientia 37, 602–603 (1981). https://doi.org/10.1007/BF01990074

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