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Mechanism of reaction of carcinogen N-acetoxy-2-acetylaminofluorene with DNA

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Summary

Scavenging studies are supporting the notion that triplet radical cations are formed during the binding of the carcinogen N-acetoxy-2-acetylamino-fluorene to native DNA in vitro.

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Author notes

  1. A. M. Bobst

    Present address: Department of Chemistry, University of Cincinnati, 45221, Cincinnati, OH, USA

Authors and Affiliations

  1. Department of Carcinogenesis, Swiss Institute for Experimental Cancer Research, CH-1066, Epalinges s/ Lausanne, Switzerland

    A. M. Bobst, T. V. Wang & P. A. Cerutti

Authors
  1. A. M. Bobst
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  2. T. V. Wang
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  3. P. A. Cerutti
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Additional information

This work was supported by Grant No.3305.78 of the Swiss National Science Foundation and by a grant from The Roche Research Foundation.

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Bobst, A.M., Wang, T.V. & Cerutti, P.A. Mechanism of reaction of carcinogen N-acetoxy-2-acetylaminofluorene with DNA. Experientia 37, 597–598 (1981). https://doi.org/10.1007/BF01990071

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  • DOI: https://doi.org/10.1007/BF01990071

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