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Na*-independent binding of [3H] muscimol to a membrane fraction of the brains of normal and dwarf mice

Summary

Although their body weights were decreased by about 77% and their brain weights by about 30%, high-affinity [3H] muscimol binding to a cerebral membrane fraction was not altered in hereditary pituitary dwarf mice. Marked changes in the level of pituitary growth-associated hormones do not appear to be associated with a change in cerebral GABA-receptors.

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Supported by a UNESCO/IBRO Fellowship. Permanent address: Semmelweis University Medical School, 1st Institute of Biochemistry, Budapest, Hungary.

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Varga, V., DeFeudis, F.V., Ossola, L. et al. Na*-independent binding of [3H] muscimol to a membrane fraction of the brains of normal and dwarf mice. Experientia 37, 594–595 (1981). https://doi.org/10.1007/BF01990069

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  • DOI: https://doi.org/10.1007/BF01990069

Keywords

  • Body Weight
  • Membrane Fraction
  • Marked Change
  • Muscimol
  • Brain Weight