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Effect of acetylsalicylic acid on iron absorption in the rat

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Summary

The in vivo administration of59Fe to the rat accompanied by acetylsalicylic acid (ASA) enhanced significantly counts in blood, spleen, liver and femur without affecting those of the intestine. The results suggest that ASA augments iron absorption either via an inhibitory action on the synthesis of prostaglandins or by a purely chemical mechanism.

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Authors and Affiliations

  1. Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), V. de Obligado 2490, 1428, Buenos Aires, Argentina

    P. Glikman, A. Gutnisky, M. F. Gimeno & A. L. Gimeno

  2. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), V. de Obligado 2490, 1428, Buenos Aires, Argentina

    P. Glikman, A. Gutnisky, M. F. Gimeno & A. L. Gimeno

Authors
  1. P. Glikman
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  2. A. Gutnisky
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  3. M. F. Gimeno
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  4. A. L. Gimeno
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Additional information

This work was supported by Grant No. 6638 from CONICET (Argentina).

The technical assistance of Mrs María E. Castro and Mrs Patricia Dubra is gratefully acknowledged.

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Glikman, P., Gutnisky, A., Gimeno, M.F. et al. Effect of acetylsalicylic acid on iron absorption in the rat. Experientia 37, 589–590 (1981). https://doi.org/10.1007/BF01990066

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