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Antimicrobial activity of ten macrolide, linsosamine and streptogramin drugs tested againstLegionella species

  • New Antimicrobial Agents
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Abstract

RP59500, a semisynthetic pristinamycin combination, and 14 other antimicrobial agents were tested against 108Legionella strains. Of the ten macrolide, lincosamine and streptogramin agents tested, the new streptogramin RP59500 ranked seventh in order of activity againstLegionella pneumophila on the basis of MIC90 results as follows: clarithromycin = 14-OH clarithromycin (MIC90 0.12 mg/l) > roxithromycin > erythromycin = tylosin = virginiamycin > RP59500 (MIC90 1 mg/l) = azithromycin > dirithromycin > clindamycin (MIC90 8 mg/l). Of all 14 drugs tested in this study, rifampicin was the most potent with an MIC90 of 0.008 mg/l. In this retrospective study ofLegionella strains (1981–1990 isolates), we observed no trend toward resistance to the agents investigated.

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Authors and Affiliations

  1. Department of Pathology, 5232 RCP, University of Iowa College of Medicine, 52242, Iowa City, Iowa, USA

    D. M. Johnson, M. E. Erwin, M. S. Barrett, B. Briggs Gooding & R. N. Jones

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  1. D. M. Johnson
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  2. M. E. Erwin
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  3. M. S. Barrett
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  4. B. Briggs Gooding
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  5. R. N. Jones
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Johnson, D.M., Erwin, M.E., Barrett, M.S. et al. Antimicrobial activity of ten macrolide, linsosamine and streptogramin drugs tested againstLegionella species. Eur. J. Clin. Microbiol. Infect. Dis. 11, 751–755 (1992). https://doi.org/10.1007/BF01989985

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