Pharmaceutisch Weekblad

, Volume 13, Issue 5, pp 207–209 | Cite as

Ofloxacin intravenous

Compatibility with other antibacterial agents
  • R. Janknegt
  • T. Stratermans
  • J. Cilissen
  • J. J. H. M. Lohman
  • P. M. Hooymans
Articles

Abstract

The physical and chemical compatibility of ofloxacin (infusion solution 100 ml=200 mg) with amoxicillin, amoxicillin+clavulanic acid, flucloxacillin, tobramycin, gentamicin, clindamycin, vancomycin, ceftazidime and piperacillin was investigated. Upon admixture with flucloxacillin a precipitate formed between 7 and 24 hours. No other physical or chemical incompatibilities were observed with any of the other combinations. Ofloxacin may be safely combined with the tested antimicrobial drugs, except for flucloxacillin.

Keywords

Antibiotics Compatibility Drug combinations Flucloxacillin Ofloxacin Precipitation 

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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1991

Authors and Affiliations

  • R. Janknegt
    • 1
  • T. Stratermans
    • 1
  • J. Cilissen
    • 1
  • J. J. H. M. Lohman
    • 1
  • P. M. Hooymans
    • 1
  1. 1.Department of Clinical PharmacyMaasland HospitalMB Sittardthe Netherlands

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