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, Volume 34, Issue 3–4, pp 387–392 | Cite as

Inhibitory effect of econazole on the release of thromboxanes

  • S. Jancar
  • C. F. P. Teixeira
  • W. Tavares de Lima
  • A. Y. Hoshikawa Fujimura
  • P. Sirois
Inflammation and Immunomodulation

Abstract

The effect of econazole on the release of thromboxanes was investigated. It was found that econazole inhibited concentration-dependently the aggregation of guinea pig platelets stimulated with arachidonic acid. The compound also reduced significantly the LTB4-induced contraction of guinea pig lung parenchyma strips and the contraction of rabbit aorta to the effluent of LTD4-stimulated guinea pig lungs, both effects mediated mostly by thromboxane generation. The concentration of TXB2 in the effluents from LTD4 stimulated lungs, assayed by EIA, was significantly reduced following pretreatment of the lungs with 10−4M and 10−5M of econazole, whereas the levels of PGE2 were increased. These results demonstrate that econazole is a selective inhibitor of thromboxane synthesis.

Keywords

Arachidonic Acid PGE2 Selective Inhibitor Thromboxane Lung Parenchyma 

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Copyright information

© Birkhäuser Verlag 1991

Authors and Affiliations

  • S. Jancar
    • 1
  • C. F. P. Teixeira
    • 2
  • W. Tavares de Lima
    • 1
  • A. Y. Hoshikawa Fujimura
    • 3
  • P. Sirois
    • 4
  1. 1.Departamento de Imunologia, Instituto de Ciências BiomédicasUniversidade de São PauloSão PauloBrasil
  2. 2.Serviço de FarmacologiaInstituto ButantãSão PauloBrasil
  3. 3.Departamento de Análises Clínicas, Faculdade de Ciências FarmaceuticasUSPSão PauloBrasil
  4. 4.Département de Pharmacologie, Faculté de MedicineUniversité de SherbrookeCanada

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