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Myocardial infarction and histamine release

Agents and Actions volume 18, pages 258–261 (1986)Cite this article

Abstract

On the basis of previous data suggesting the involvement of cardiac histamine in ischemic heart disease (IHD), we evaluated plasma histamine (H) and creatine-kinase isoenzyme (CK-MB) level in cardiac and healthy subjects.

20 patients with acute myocardial infarction (AMI) (10 developing AMI in Hospital, thus making possible the detection of plasma H level before acute event), 10 patients with IHD not developing AMI and 10 presumably healthy subjects were admitted to the study.

15 of all patients with AMI showed a correlated H and CK-MB trend during AMI reaching the highest peak 24 hours after onset of pain.

7 of the patients with IHD who developed AMI in Hospital showed a slightly higher plasma H level, before AMI, than those with IHD who did not develop AMI.

A possible role of histamine in the pathogenesis of AMI is discussed.

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Affiliations

  1. Clinica Medica III, University of Bologna, Italy

    F. Zaca, M. S. Benassi, M. Ghinelli, M. Trianni, R. Vaccarino, E. Malavolta, M. Muratori & S. Lenzi

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  1. F. Zaca
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  2. M. S. Benassi
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  3. M. Ghinelli
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  4. M. Trianni
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  5. R. Vaccarino
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  6. E. Malavolta
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  7. M. Muratori
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  8. S. Lenzi
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Zaca, F., Benassi, M.S., Ghinelli, M. et al. Myocardial infarction and histamine release. Agents and Actions 18, 258–261 (1986). https://doi.org/10.1007/BF01988036

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  • DOI: https://doi.org/10.1007/BF01988036

Keywords

  • Myocardial Infarction
  • Heart Disease
  • Healthy Subject
  • Histamine
  • Acute Myocardial Infarction