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FMLP-activated neutrophils evoke histamine release from mast cells

  • Histamine and Immunology
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Human neutrophils, having been activated by the chemotactic peptide N-formylmethionyl-leucyl-phenylalanine (FMLP), evoke histamine release from rat serosal mast cells. The release is dependent on FMLP concentration and it can be inhibited by disodium cromoglycate and by a flavonoid, silymarin, which displays free radical scavenging properties. Silymarin inhibition of neutrophil-mediated histamine release is dose-dependent. These results further stress the concept of a neutrophil-mast cell interaction, which may be involved in inflammatory processes.

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Fantozzi, R., Brunelleschi, S., Rubino, A. et al. FMLP-activated neutrophils evoke histamine release from mast cells. Agents and Actions 18, 155–158 (1986).

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