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Agents and Actions

, Volume 18, Issue 1–2, pp 155–158 | Cite as

FMLP-activated neutrophils evoke histamine release from mast cells

  • R. Fantozzi
  • S. Brunelleschi
  • A. Rubino
  • S. Tarli
  • E. Masini
  • P. F. Mannaioni
Histamine and Immunology

Abstract

Human neutrophils, having been activated by the chemotactic peptide N-formylmethionyl-leucyl-phenylalanine (FMLP), evoke histamine release from rat serosal mast cells. The release is dependent on FMLP concentration and it can be inhibited by disodium cromoglycate and by a flavonoid, silymarin, which displays free radical scavenging properties. Silymarin inhibition of neutrophil-mediated histamine release is dose-dependent. These results further stress the concept of a neutrophil-mast cell interaction, which may be involved in inflammatory processes.

Keywords

Peptide Mast Cell Histamine Flavonoid Inflammatory Process 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag 1986

Authors and Affiliations

  • R. Fantozzi
    • 1
  • S. Brunelleschi
    • 1
  • A. Rubino
    • 1
  • S. Tarli
    • 1
  • E. Masini
    • 1
  • P. F. Mannaioni
    • 1
  1. 1.Department of Preclinical and Clinical PharmacologyUniversity of FlorenceFlorenceItaly

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