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FMLP-activated neutrophils evoke histamine release from mast cells

  • Histamine and Immunology
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Abstract

Human neutrophils, having been activated by the chemotactic peptide N-formylmethionyl-leucyl-phenylalanine (FMLP), evoke histamine release from rat serosal mast cells. The release is dependent on FMLP concentration and it can be inhibited by disodium cromoglycate and by a flavonoid, silymarin, which displays free radical scavenging properties. Silymarin inhibition of neutrophil-mediated histamine release is dose-dependent. These results further stress the concept of a neutrophil-mast cell interaction, which may be involved in inflammatory processes.

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Authors and Affiliations

  1. Department of Preclinical and Clinical Pharmacology, University of Florence, V. le G.B. Morgagni 65, 50134, Florence, Italy

    R. Fantozzi, S. Brunelleschi, A. Rubino, S. Tarli, E. Masini & P. F. Mannaioni

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  1. R. Fantozzi
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  2. S. Brunelleschi
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  3. A. Rubino
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  4. S. Tarli
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  5. E. Masini
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  6. P. F. Mannaioni
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Fantozzi, R., Brunelleschi, S., Rubino, A. et al. FMLP-activated neutrophils evoke histamine release from mast cells. Agents and Actions 18, 155–158 (1986). https://doi.org/10.1007/BF01988009

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  • DOI: https://doi.org/10.1007/BF01988009

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