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, Volume 18, Issue 1–2, pp 137–140 | Cite as

The influence of guanidino and isothiourea groups in histaminergic compounds on H2-activity

  • G. J. Sterk
  • H. van der Goot
  • H. Timmerman
Histamine Receptors-Agonists and Antagonists


Because in some alkylenediisothioureas replacement of one of the isothiourea groups by a guanidino group resulted in a strong increase in agonistic histamine H2-activity, while replacement of the guanidino group of a potent analogue of impromidine by an isothiourea group resulted in a complete loss of histamine H2-activity, it was concluded that guanidino and isothiourea groups are not bio-isosteric for the H2-receptor.


Histamine Complete Loss Strong Increase Guanidino Potent Analogue 
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Copyright information

© Birkhäuser Verlag 1986

Authors and Affiliations

  • G. J. Sterk
    • 1
  • H. van der Goot
    • 1
  • H. Timmerman
    • 1
  1. 1.Department of PharmacochemistryVrije UniversiteitAmsterdamThe Netherlands

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