The influence of guanidino and isothiourea groups in histaminergic compounds on H2-activity
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Because in some alkylenediisothioureas replacement of one of the isothiourea groups by a guanidino group resulted in a strong increase in agonistic histamine H2-activity, while replacement of the guanidino group of a potent analogue of impromidine by an isothiourea group resulted in a complete loss of histamine H2-activity, it was concluded that guanidino and isothiourea groups are not bio-isosteric for the H2-receptor.
KeywordsHistamine Complete Loss Strong Increase Guanidino Potent Analogue
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