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, Volume 18, Issue 1–2, pp 137–140 | Cite as

The influence of guanidino and isothiourea groups in histaminergic compounds on H2-activity

  • G. J. Sterk
  • H. van der Goot
  • H. Timmerman
Histamine Receptors-Agonists and Antagonists

Abstract

Because in some alkylenediisothioureas replacement of one of the isothiourea groups by a guanidino group resulted in a strong increase in agonistic histamine H2-activity, while replacement of the guanidino group of a potent analogue of impromidine by an isothiourea group resulted in a complete loss of histamine H2-activity, it was concluded that guanidino and isothiourea groups are not bio-isosteric for the H2-receptor.

Keywords

Histamine Complete Loss Strong Increase Guanidino Potent Analogue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Birkhäuser Verlag 1986

Authors and Affiliations

  • G. J. Sterk
    • 1
  • H. van der Goot
    • 1
  • H. Timmerman
    • 1
  1. 1.Department of PharmacochemistryVrije UniversiteitAmsterdamThe Netherlands

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