Two different dosages of ciprofloxacin in patients with respiratory tract infections


Fifty-one patients with chronic obstructive lung disease with a proven bacterial respiratory tract infection were treated with ciprofloxacin 500 mg twice daily or 750 mg twice daily. Both dosages were given orally for approximately 10 days. The higher dosage showed a reduced amount of reinfections and relapses (19% and 16% versus 5% and 0%). The overall results were the same in both groups. Adverse reactions were mild: nausea and visual disturbances were seen in five patients. Eights patients had slight liver test abnormalities. In one patient a seizure occurred. All adverse reactions were of a temporary nature.

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Correspondence to Dr. T. Brutel de la Rivière.

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de la Rivière, T.B., Daniëls-Bosman, M.S.M. & ten Velde, G.P.M. Two different dosages of ciprofloxacin in patients with respiratory tract infections. Pharmaceutisch Weekblad Scientific Edition 11, 121–123 (1989).

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  • Ciprofloxacin
  • Pulmonary diseases, chronic obstructive
  • Respiratory tract infections