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, Volume 37, Issue 1–2, pp 114–120 | Cite as

Hepatoprotective effects of lobenzarit disodium on acetaminophen-induced liver damage in mice

  • Ricardo González
  • Carlos Pascual
  • Odelsa Ancheta
  • Berta Carreras
  • Diadelis Remírez
  • Rolando Pellón
Inflammation and Immunomodulation

Abstract

We have studied the effects of the immunomodulator drug lobenzarit in the model of acute hepatotoxicity induced by a high oral dose (600 mg/kg) of acetaminophen in mice. Lobenzarit at doses of 25, 50 and 100 mg/kg i.p. decreased significantly the activity of alanine aminotransferase in serum, which was increased by acetaminophen alone, and increased the concentration of reduced glutathione in mice liver, which is depleted by acetaminophen.

Lobenzarit also reduced liver damage induced by acetaminophen in mice, which was observed by electron microscopy. The hepatoprotective effects of lobenzarit were dose-dependent and they were produced when lobenzarit was administered 30 min before acetaminophen or 2 and 4 h after it. It is concluded that lobenzarit exerts some effects which resemble those of an antidote of acetaminophen such asN-acetylcysteine.

Keywords

Electron Microscopy Glutathione Alanine Oral Dose Acetaminophen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag 1992

Authors and Affiliations

  • Ricardo González
    • 1
  • Carlos Pascual
    • 1
  • Odelsa Ancheta
    • 1
  • Berta Carreras
    • 1
  • Diadelis Remírez
    • 1
  • Rolando Pellón
    • 1
  1. 1.Department of PharmacologyNational Center for Scientific ResearchHavanaCuba

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