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, Volume 43, Issue 3–4, pp 176–178 | Cite as

Inhibition of arachidonic acid cyclo-oxygenase and lipoxygenase activities of leukocytes by indomethacin and compound BW755C

  • R. W. Randall
  • K. E. Eakins
  • G. A. Higgs
  • J. A. Salmon
  • J. E. Tateson
Article

Abstract

Arachidonic acid is metabolized via two pathways in leukocytes: cyclo-oxygenase, leading to the stable prostaglandins, and lipoxygenase, leading to hydroxyacids. Indomethacin inhibits the cyclo-oxygenase selectively, whereas compound BW755C (3-amino-1-(m-(trifluoromethyl)phenyl)-2-pyrazoline) inhibits both pathways equally. This offers a possible explanation for the differing activities of these two compounds in inflammatory models in vivo. The patterns of product inhibition by the two compounds support the suggestion that 11-HETE (hydroxy-eicosatetraenoic acid) and 15-HETE can arise by incomplete operation of the cyclo-oxygenase pathway.

Keywords

Phenyl Prostaglandin Arachidonic Acid Indomethacin Trifluoromethyl 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag 1994

Authors and Affiliations

  • R. W. Randall
    • 1
  • K. E. Eakins
    • 1
  • G. A. Higgs
    • 1
  • J. A. Salmon
    • 1
  • J. E. Tateson
    • 1
  1. 1.Department of Pharmacology and Prostaglandin ResearchWellcome Research LaboratoriesBeckenhamUK

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