9-α-hydroxyparthenolide, a novel antitumor sesquiterpene lactone fromAnvillea garcini (Burm.) DC1
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A novel sesquiterpene lactone, 9-α-hydroxyparthenolide (1) was isolated from a chloroform extract ofAnvillea garcini that was collected in Iran. The structure of1 was assigned on the basis of high field NMR decoupling experiments and other spectroscopic evidence. This α-methylene lactone has shown significant activity in both the 9KB cell culture and P388 mouse leukemia test systems.
KeywordsCell Culture Leukemia Chloroform Lactone Significant Activity
- 3.Collected in April 1976 near Hajiabad, 100 km north of the Persian Gulf and air dried in the shade. Voucher specimens are deposited in the herbarium of the Department of Pharmacognosy, University of Tehran, under No. 408 and were identified by Professor Karl Humel, Tübingen University, and Mr C.H. Amin, University of Tehran.Google Scholar
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