Summary
The cerebral insufficiency improvers centrophenoxine, piracetam and hydergine were tested for their effect on lipid peroxidation of rat brain homogenates, both in vitro and in vivo. There was no effect either in vitro or after chronic 8 week dosing of animals.
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L. Packer, D. W. Deamer and R. L. Health, Adv. geront. Res.2, 77 (1967).
W. P. Johnson, D. Jefferson and C. E. Mengel, J. clin. Invest.51, 2211 (1972).
A. Tappel, B. Fletcher and D. Deamer, J. Geront.28, 415 (1973).
S. A. Jerrett, D. Jefferson and C. E. Mengel, Aerospace Med.44, 40 (1973).
J. Miquel and P. R. Lundgren, Nasa Tech. Brief.B75, 10030 (1975).
H. F. Thomas, R. M. Hernot, B. S. Hahn and S. Y. Wang, Nature259, 341 (1976).
K. Nishiki, D. Jamieson, N. Oshino and B. Chance, Biochem. J.160, 343 (1977).
A. L. Tappel, Adv. exp. Med. Biol.97, 111 (1977).
G. L. Plaa and H. Witschi, A. Rev. Pharmac. Tox.16, 125 (1976).
T. J. Player, D. J. Mills and A. A. Horton, Biochem. biophys. Res. Commun.78, 1397 (1977).
H. Nohl and D. Hegner, Eur. J. Biochem.82, 563 (1978).
D. H. Boehme, R. Kosecki, S. Carson, F. Stern and N. Marks, Brain Res.136, 11 (1977).
O. P. Sharma, Biochem. biophys. Res. Commun.78, 469 (1977).
J. Charbaut, J. Roggy and B. Mourey, Annls méd.-psychol.131, 281 (1973).
P. H. Guilmot and R. Van Ex, Archs Méd.30, 791 (1975).
K. Nandy, Anat. Rec.181, 433 (1975).
K. Nandy, J. Am. Geriat. Soc.26, 74 (1978).
A. Dresse, Rev. Med., Liège31, 722 (1976).
M. Pesh-Imam and R. O. Recknagel, Toxic. appl. Pharmac.42, 463 (1977).
L. Gustafson, J. Risberg, M. Johanson, M. Fransson and V. A. Maximilian, Psychopharmacology56, 115 (1978).
K. Nandy, J. Geront.23, 82 (1968).
M. Hasan, P. Glees and P. E. Spoerri, Cell Tissue Res.150, 369 (1974).
F. H. Schneider and K. Nandy, J. Geront.32, 132 (1977).
P. Glees and M. Hasan, Norm. Path. Anat., Stuttg.32, 1 (1976).
H. Shimasaki, T. Nozawa, O. S. Privett and W. R. Anderson, Archs Biochem. Biophys.183, 443 (1977).
H. Kappus, H. Kieczka, M. Scheulen and H. Remmer, Naunyn-Schmiedebergs Arch. Pharmak.300, 179 (1977).
A. Bindoli, L. Cavallini and N. Siliprand, Biochem. Pharmac.26, 2405 (1977).
K. Domanska-Janik and M. Zaleska, Pol. Pharmac. Pharm.29, 111 (1977).
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Jamieson, D.D., Taylor, K.M. Effects of centrophenoxine, piracetam and hydergine on rat brain lipid peroxidation. Experientia 37, 879–881 (1981). https://doi.org/10.1007/BF01985691
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DOI: https://doi.org/10.1007/BF01985691