, Volume 37, Issue 8, pp 807–809 | Cite as

The serum levels of unbound bilirubin that induce changes in some brain mitochondrial reactions in newborn guinea-pigs

  • Maria A. S. Almeida
  • L. RezendeJr


Bilirubin in different concentrations was injected in newborn guinea-pigs and the following parameters were determined: serum total and unbound bilirubin, whole brain bilirubin content and oxygen consumption, NADH-cytochrome c reductase and ATPase activities in brain mitochondria. The results showed a significant correlation between decreased rates of brain metabolism and the elevation of serum total and unbound bilirubin.


Oxygen Serum Level Bilirubin Oxygen Consumption ATPase Activity 
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  1. 3.
    H.M. Zimmerman and H. Yannet, Am. J. Dis. Child.45, 740 (1933).Google Scholar
  2. 4.
    H.S. Schutta and L. Johnson, J. Neuropath. exp. Neurol.26, 377 (1967).PubMedGoogle Scholar
  3. 5.
    H.S. Schutta, L. Johnson and H.E. Neville, J. Neuropath. exp. Neurol.29, 296 (1970).PubMedGoogle Scholar
  4. 6.
    W.B. Karp, Pediatrics64, 361 (1979).PubMedGoogle Scholar
  5. 7.
    W.J. Cashore, L.M. Gartner, W. Oh and L. Stern, J. Pediatr.93, 827 (1978).PubMedGoogle Scholar
  6. 8.
    I. Diamond and R. Schmid, J. clin. Invest.45, 678 (1966).Google Scholar
  7. 9.
    R.G. Martinek, Clin. chim. Acta13, 161 (1966).CrossRefPubMedGoogle Scholar
  8. 10.
    J. Jacobsen and R.P. Wennberg, Clin. Chem.20, 783 (1974).PubMedGoogle Scholar
  9. 11.
    E.G. Gray and V.P. Whittaker, J. Anat.96, 79 (1962).PubMedGoogle Scholar
  10. 12.
    O.H. Lowry, N.J. Rosebrough, A.L. Farr and R.J. Randall, J. biol. Chem.193, 265 (1951).PubMedGoogle Scholar
  11. 13.
    R. Zetterström and L. Ernster, Nature178, 1335 (1956).PubMedGoogle Scholar
  12. 14.
    A.E. Taylor and C.W. Miller, J. biol. Chem.18, 215 (1914).Google Scholar
  13. 15.
    D.E. Green and D.M. Ziegler, in: Methods in Enzymology, vol. 6, p. 418. Academic Press, New York 1963.Google Scholar
  14. 16.
    M.G. Mustafa, M.L. Cowger and T.E. King, J. biol. Chem.244, 6403 (1969).PubMedGoogle Scholar
  15. 17.
    H. Sato and R. Semba, Experientia34, 221 (1978).CrossRefPubMedGoogle Scholar
  16. 18.
    W.J. Cashore, P.J. Monin and W. Oh, Pediatr. Res.12, 195 (1978).PubMedGoogle Scholar
  17. 19.
    H.D. Arkans and G. Cassady, J. Pediatr.92, 1001 (1978).PubMedGoogle Scholar
  18. 20.
    R.P. Wennberg, M. Lau and L.F. Rasmussen, Clin. Res.10, 434 (1976) abstract.Google Scholar

Copyright information

© Birkhäuser Verlag 1981

Authors and Affiliations

  • Maria A. S. Almeida
    • 1
  • L. RezendeJr
    • 1
  1. 1.Department of Biochemistry and Immunology of the Federal University of Minas GeraisBelo Horizonte(Brazil)

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