Summary
A description is given of a breeding experiment with mice, in which it has been proved that the males of a cancerous strain transmit the cancer-tendency to their offspring. The males of this strain never develop mammary tumours. Five males were paired with five females belonging to a cancer-free strain. No tumours of any kind appeared in the F1 generation from this cross, but in F2 there were obtained 2 mammary tumours and a number of other types of neoplasms, giving a total of 22 neoplasms in 158 does which reached cancer age.
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Pybus, F.C., Miller, E.W. The transmission of the cancer tendency by the males of a tumour strain of mice. Genetica 17, 342–348 (1935). https://doi.org/10.1007/BF01985018
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DOI: https://doi.org/10.1007/BF01985018