Glutathione plays different roles in the induction of the cytotoxic effects of inorganic and organic arsenic compounds in cultured BALB/c 3T3 cells
- 80 Downloads
The cytotoxicity of arsenic compounds towards BALB/c 3T3 cells in culture was investigated, together with the role of glutathione (GSH) in the induction of the cytotoxic effects. The rank order of cytotoxicity was as follows: arsenite (As3+)>arsenate (As5+)>dimethylarsinic acid (DMAA)>methylarsonic acid (MAA)>trimethylarsine oxide (TMAO). Arsenobetaine, arsenocholine and the tetramethylarsonium ion were less toxic. Depletion of GSH enhanced the cytotoxic effects of As3+, As5+, MAA and TMAO, while the cytotoxicity of DMAA was markedly reduced by depletion of GSH. These results suggest that GSH plays a role in protecting the cells against the toxic effects of As3+, As5+, MAA and TMAO while it is involved in the induction of the cytotoxic effects of DMAA.
Key wordsArsenic compounds cytotoxicity BALB/c 3T3 cells glutathione depletion
Unable to display preview. Download preview PDF.
- 4.Yamauchi, H., and Yamamura, Y., Indust. Health17 (1979) 79.Google Scholar
- 12.Fowler, B. A., Advances in Modern Toxicology, vol. 2, Toxicology of Trace Elements, p. 79. Eds. R. A. Goyer and M. A. Mehlman. Hemisphere Publishing Corporation, Washington 1977.Google Scholar
- 13.Webb, J. L., Enzyme and metabolic inhibitors, vol. 3, p. 595. Academic Press, New York 1966.Google Scholar
- 21.Edmonds, J. S., and Francesconi, K. A., Nature, London289 (1981) 602.Google Scholar