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, Volume 42, Issue 3–4, pp 114–117 | Cite as

Anti-inflammatory and antipyretic effects of boldine

  • N. Backhouse
  • C. Delporte
  • M. Givernau
  • B. K. Cassels
  • A. Valenzuela
  • H. Speisky
Inflammation

Abstract

Boldine, and antioxidant alkaloid isolated fromPeumus boldus, exhibits a dose-dependent anti-inflammatory activity in the carrageenan-induced guinea pig paw edema test with an oral ED50 of 34 mg/kg. Boldine also reduces bacterial pyrogen-induced hyperthermia in rabbits to an extent which varied between 51% and 98% at a dose of 60 mg/kg p.o.In vitro studies carried out in rat aortal rings revealed that boldine is an effective inhibitor of prostaglandin biosynthesis, promoting 53% inhibition at 75 μM. The latterin vitro effect may be mechanistically linked to the anti-inflammatory and antipyretic effects of boldine exertedin vivo.

Key words

Inflammation Fever Prostanoid biosynthesis Boldine Antioxidants 

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Copyright information

© Birkhäuser Verlag 1994

Authors and Affiliations

  • N. Backhouse
    • 1
  • C. Delporte
    • 1
  • M. Givernau
    • 2
  • B. K. Cassels
    • 3
  • A. Valenzuela
    • 4
  • H. Speisky
    • 4
  1. 1.Departamento de Quimica Farmacológica y Toxicológica, Facultad de Ciencias Químicas y FarmacéuticasUniversidad de ChileSantigoChile
  2. 2.Departmento de Farmacología, Facultad de MedicinaUniversidad de ChileSantigoChile
  3. 3.Departamento de Química, Facultad de CienciasUniversidad de ChileSantigoChile
  4. 4.Unidad de Bioquímica Farmacológica y Lipidos, INTAUniversidad de ChileSantigoChile

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