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European Journal of Pediatrics

, Volume 153, Issue 6, pp 419–423 | Cite as

A clinical trial with an “anti-regurgitation” formula

  • Yvan Vandenplas
  • Said Hachimi-Idrissi
  • Ann Casteels
  • Tania Mahler
  • Helmuth Loeb
Gastroenterology/Hepatology

Abstract

To determine whether a new “anti-regurgitation formula” containing a bean gum preparation decreases the number of regurgitations and gastro-oesophageal reflux (GOR), we studied 20 infants from 1 week to 4 months of age, referred for evaluation of regurgitation, in a double-blind prospective study. The number of regurgitations decreased significantly in both the treatment group (the formula with thickening product, positional treatment, parental reassurance) and the placebo group (the same formula without thickening product, positional treatment, parental reassurance) (P 0.002 and 0.032, respectively). The results of a 24-h oesophageal pH monitoring, performed before and during treatment, showed a significant decrease in the percentage of time oesophageal pH was <4.0 in the treatment group. It is concluded that conservative treatment of regurgitations in infants, consisting mainly of parental reassurance and postural therapy, is sufficient to obtain clinical remission in most patients. In addition, milk thickening products tend to improve clinical remission and contribute to the normalisation of some pH metric parameters.

Key words

Gastro-oesophageal reflux Infants Thickening Bean gum Oesophageal pH monitoring 

Abbreviations

GOR

gastrooesophageal reflux

IgE

immunoglobulin E

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Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • Yvan Vandenplas
    • 1
  • Said Hachimi-Idrissi
    • 1
  • Ann Casteels
    • 1
  • Tania Mahler
    • 1
  • Helmuth Loeb
    • 1
  1. 1.Academic Children's HospitalFree University of BrusselsBrusselsBelgium

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