Conclusion
The anti-inflammatory and analgesic activities of theDl-2-phenylglycine octyl ester can be increased by alkoxy groups at the phenyl ring. The increase of these activities differs in the various tests used. Regarding the acute toxicity, the 4-(5.5-dimethylhexyloxy) group has the most marked influence on the efficacy. Further investigations are necessary to characterize this substance in detail.
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References
E. Schulz, W.-D. Sprung, G. Kröning and G. Vietinghoff,Zur Synthese und pharmakologischen Wirksamkeit homologer n-Alkylester des dl-2-Pheylglycins. Pharmazie33, 749–753 (1978).
E. Schulz, W.-D. Sprung, G. Kröning and P. Lange,Pharmacological properties of Dl-2-phenylglycine alkylesters with special consideration of their anti-inflammatory activity. Agents and Actions [Suppl.]10, 119–128 (1982).
E. Schulz, W.-D. Sprung and M. Kobow,Zur pharmakologischen Wirksamkeit p-substituierter Dl-2-Phenylglycinoctylester. Pharmazie45, 925–928 (1990).
C.S. Weil,Tables for convenient calculation of median-effective dose (LD 50 or ED 50)and instruction in their use. Biometrics 249–262 (1952).
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Schulz, E., Kobow, M. & Sprung, W.D. Analgesic and anti-inflammatory activity ofDl-2-(alkoxyphenyl)glycine octyl esters. Agents and Actions 32, 65–66 (1991). https://doi.org/10.1007/BF01983313
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DOI: https://doi.org/10.1007/BF01983313