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, Volume 16, Issue 3–4, pp 287–290 | Cite as

Evidence of mast-cell histamine being mitogenic in intact tissue

  • Klas Norrby
Histamine in Pathological States


We have reported previously that secretion by connective tissue mast cells (MCs) causes mitogenesis in adjacent cells in diverse rat tissues.

In cultured rat mesentery there was a spontaneous release of about 45% of the histamine in 2 days, and a spontaneous marked increase in basal proliferation of the mesentery. The MC secretagogues, compound 48/80 and polymyxin B, released additional histamine and stimulated mitogenesis further. In contrast, 48/80 added to cultures of guinea-pig mesentery, the MC of which are unresponsive to the drug, did not affect the basal proliferation. However, exogenous histamine at 10−10M mitogenically stimulated the cultured guinea-pig mesentery. A histmaine H2-receptor antagonist, which itself was mitogenically inert, significantly suppressed the 48/80-induced MC-mediated mitogenesis in rat mesenteryin vivo andin vitro. On the other hand, a histamine H1-receptor antagonist did not affect this MC-mediated mitogenesis in rat.

Our findings indicate that histamine is one of possibly several mitogens which are released or activated by the secreting MC.


Mast Cell Connective Tissue Histamine Adjacent Cell Polymyxin 
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Copyright information

© Birkhäuser Verlag 1985

Authors and Affiliations

  • Klas Norrby
    • 1
  1. 1.Department of PathologyUniversity of LinköpingSweden

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