Agents and Actions

, Volume 16, Issue 3–4, pp 249–251 | Cite as

Diamine oxidase content in urine of patients with renal failure

  • D. Giarnieri
  • M. T. Costa
  • V. Giarnieri
  • B. Mondovi
Histamine in Pathological States


Diamine oxidase activity was determined in twentyseven samples collected from normal subjects and from patients with renal failure. The enzyme activity was absent or very low in the urine samples of normal subjects. The highest diamine oxidase activity was found in the patients affected with nephrosis, the Fanconi syndrome and renal transplantation, showing a relationship between urinary enzymatic activity and tubular damage, in accordance with the localization in the convoluted tubules.


Enzymatic Activity Renal Failure Urine Sample Renal Transplantation Diamine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. [1]
    E.A. Zeller,Uber den enzymatischen Abbau von Histamin and Diaminen, Helv. chim. Acta21, 880–890 (1938).CrossRefGoogle Scholar
  2. [2]
    M.P. Argento-Cerù, A. Oratore, B. Mondovì andA. Finazzi-Agrò,Localization of diamine oxidase in pig kidney. Immunofluorescence method, Cell and molec. Biol.27, 359–362 (1981).Google Scholar
  3. [3]
    J.D. Kopple, C. Fai Tam, M. Wang andM.E. Swendscid,Diamine oxidase in renal failure, Kidney Intern.13, 520–525 (1978).Google Scholar
  4. [4]
    M.A. Desiderio, A. Sessa andA. Perin,Induction of diamine oxidase activity in rat kidney during compensatory hypertrophy, Biochim. biophys. Acta714, 243–249 (1982).PubMedGoogle Scholar
  5. [5]
    H. Tabor andC.W. Tabor,Biosynthesis and metabolism of 1,4-diaminobutane, spermidine, spermine and related amines, Adv. Enzymol.36, 203–268 (1972).PubMedGoogle Scholar
  6. [6]
    D.A. Feinfeld, G.M. Fleischner, E.J. Goldstein, R.D. Levine, S.D. Levine, M.M. Arram andI.M. Aries, Ligandinuria: an indication of tubular cell necrosis. InDiagnostic Significance of Enzymes and Proteins in Urine (EdsJ.C. Dubach andU. Schmidt) Hans Huber Publ., Bern, Stuttgart, Vienna 1979. pp. 273–280.Google Scholar
  7. [7]
    V. Glover, M.A. Reveley andM. Sandler,A monoamine oxidase inhibitor in human urine, Biochem. Pharmac.29, 467–470 (1980).CrossRefGoogle Scholar
  8. [8]
    B. Mondovi, G. Rotilio, M.T. Costa andA. Finazzi-Agrò. Diamine oxidase (pig kidney). InMethods in Enzymology 1971, vol. XVIIB, pp. 735–740 (EdsH. Tabor andC.W. Tabor), Acad. Press publ., New York and London.Google Scholar
  9. [9]
    T. Okuyama andY. Kobayashi,Determination of diamine oxidase activity by liquid scintillation counting, Arch. Biochem. Biophys.95, 242–250 (1961).CrossRefPubMedGoogle Scholar
  10. [10]
    V. Gäng, H. Berneburg, H. Hennemann andG. Hevendehl,Diamine oxidase (histaminase) in chronic renal disease and its inhibition ‘in vitro’ by methylguanidine, Clin. Nephrol.5, 171–176 (1976).Google Scholar

Copyright information

© Birkhäuser Verlag 1985

Authors and Affiliations

  • D. Giarnieri
    • 1
  • M. T. Costa
    • 1
  • V. Giarnieri
    • 1
  • B. Mondovi
    • 1
  1. 1.Institute of Applied BiochemistryUniversity of Rome and C.N.R. Center of Molecular BiologyRome

Personalised recommendations