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Central histaminergic stimulation of hyperlipemic response in rats under stress

  • Histamine in the Central Nervous System
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Abstract

In rats subjected to a mild stress of immobilization histamine, the H1-receptor agonist 2-pyridylethylamine (PEA), and the H2-receptor agonists 4-methyl histamine (4-MeHA) and impromidine administered intracerebroventricularly (i.c.v.) 1 h prior to stress, intensified the stress-induced increase in serum free fatty acid (FFA) levels. Impromidine was far more potent than histamine and its agonists in increasing hyperlipemia in stressed rats. The hyperlipemic response to histamine was abolished by i.c.v. pretreatment of rats with mepyramine, a H1-receptor antagonist, but was unchanged in rats pretreated with cimetidine or metiamide, H2-receptor antagonists. The increase in serum FFA levels induced in stressed rats by PEA was abolished by mepyramine but the hyperlipemic responses to 4-MeHA and impromidine were not antagonized by cimetidine.

These results suggest that central H1-receptor mediate the histamine-stimulated hyperlipemic response in stressed rats.

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References

  1. J. Bugajski andZ. Janusz,Lipolytic responses induced by intracerebroventricular administration of histamine in the rat, Agents and Actions11, 147–150 (1981).

    PubMed  Google Scholar 

  2. J.E. Shaw andP.W. Ramwell,Release of prostaglandin from rat epidymal fat pad on nervous and hormonal stimulation, J. biol. Chem.243, 1498–1503 (1969).

    Google Scholar 

  3. C. Rudolph, G.E. Richards, S. Kaplan andW.F. Ganong,Effects of intraventricular histamine on hormone secretion in dogs, Neuroendrocrinology29, 169–177 (1979).

    Google Scholar 

  4. J. Bugajski andZ. Janusz,Central histaminergic stimulation of pituitary-adrenocortical response in the rat, Life Sci.33, 1179–1189 (1983).

    Article  PubMed  Google Scholar 

  5. J. Bugajski andAnna Gaądek,Central H 1-and H 2-histaminergic stimulation of pituitary-adrenocortical response under stress in rats, Neuroendocrinology36, 424–430 (1983).

    PubMed  Google Scholar 

  6. J.E. Dimsdale andJ.A. Herd,Variability of plasma lipids in response to emotional arousal, Psychosom. Med.44, 413–430 (1982).

    PubMed  Google Scholar 

  7. G.J. Durant, W.A.M. Duncan, C.R. Ganellin, M.E. Parsons, R.C. Blakemore andA.C. Rasmussen,Impromidine (SK § F 92676) is a very potent and specific agonist for histamine H 2 receptors, Nature, Lond.276, 403–405 (1978).

    Google Scholar 

  8. G. Bertaccini andG. Coruzzi,Evidence for and against heterogenity in the histamine H 2-receptor population, Pharmacology23, 1–13 (1981).

    PubMed  Google Scholar 

  9. P.M. Gross,Cerebral histamine: indications for neuronal and vascular regulation, J. Cerebral Blood Flow and Metabolism2, 3–23 (1982).

    Google Scholar 

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Authors and Affiliations

  1. Institute of Pharmacology, Polish Academy of Sciences, Cracow, Poland

    Jan Bugajski & Anna Gądek

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  1. Jan Bugajski
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  2. Anna Gądek
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Bugajski, J., Gądek, A. Central histaminergic stimulation of hyperlipemic response in rats under stress. Agents and Actions 16, 236–239 (1985). https://doi.org/10.1007/BF01983149

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  • DOI: https://doi.org/10.1007/BF01983149

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