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, Volume 16, Issue 3–4, pp 215–218 | Cite as

Effects of three histaminergic compounds on function and oxygen consumption of isolated guinea-pig hearts

  • Bernhard Permanetter
  • Gert Baumann
  • Jochen Dörner
  • Walter Schunack
  • Hans Blömer
Histamine and Cardio-Vascular System

Abstract

First experiences in man indicate, that even in catecholamine-insensitive congestive cardiomyopathy a considerable improvement of myocardial function can be attained by the H2-receptor agonist impromidine. In an isolated, pressure-volume work performing guinea-pig heart preparation cardiac effects of three histaminergic compounds (Nα,5-dimethylhistamine (HCl)2, 5-ethyl-Nα-methyl-histamine (HCl)2,Nα,Nα-dimethyl-histamine (HCl)2) were examined. Influences on function and myocardial oxygen consumption were compared to those obtained by impromidine.

Dose-response curves for the histamine derivatives were 1.7–2.5 orders of magnitude right of the impromidine curves. Maximal inotropic stimulation was greater forNα,5-dimethyl-histamine (HCl)2 than for impromidine. All compounds exhibited a high chronotropic effect and, at high concentrations, a net coronary dilating effect.

Keywords

Histamine Cardiomyopathy Oxygen Consumption Considerable Improvement Myocardial Function 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Birkhäuser Verlag 1985

Authors and Affiliations

  • Bernhard Permanetter
    • 1
  • Gert Baumann
    • 1
  • Jochen Dörner
    • 1
  • Walter Schunack
    • 1
  • Hans Blömer
    • 1
  1. 1.1st Department of Medicine, Division Cardiology and CirculationTechnical University of MunichFRG

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